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Anti-Infectives

Tigradox®

Tigecycline
50 mg vialLyophilised powderIV infusionRx only

Tigecycline 50 mg for complicated infections, including those caused by multidrug-resistant organisms.

Tigradox® 50 mg vial
Product overview

A glycylcycline for multidrug-resistant infection

Tigradox® is tigecycline 50 mg, a lyophilised powder for intravenous infusion. A glycylcycline of the tetracycline class, it offers one agent across polymicrobial critical-care infection.

Single-agent breadth

Activity across resistant Gram-positive, Gram-negative, anaerobic and atypical pathogens.

No renal dose adjustment

No adjustment required in renal impairment or dialysis.

Fixed dosing

100 mg loading dose, then 50 mg every 12 hours. No therapeutic drug monitoring.

Indications

Therapeutic use

Complicated intra-abdominal infections and complicated skin and soft tissue infections, including those caused by multidrug-resistant organisms, and community-acquired pneumonia, as set out in the approved prescribing information.

Activity against

Resistant pathogens

  • MRSA and other resistant Gram-positive bacteria
  • VRE (vancomycin-resistant enterococci)
  • ESBL-producing Enterobacterales
  • CRE (carbapenem-resistant Enterobacterales)
  • Anaerobic and atypical pathogens
Prescribing essentials

Dosage & administration

Composition

Tigecycline 50 mg, lyophilised powder for injection. Drug class: glycylcycline (tetracycline class).

Dosage & administration

Loading dose 100 mg IV over 30–60 minutes, then 50 mg every 12 hours. Severe hepatic impairment: 25 mg every 12 hours after the loading dose. No adjustment in renal impairment or dialysis.

Storage

Store at 20–25°C; excursions permitted to 15–30°C. Once mixed in an IV bag with 0.9% sodium chloride or 5% dextrose, may be refrigerated and used within 48 hours.

Safety & precautions

See the important safety information below and the approved prescribing information.

Important safety information

  • Common adverse effects: nausea, vomiting, diarrhoea, abdominal pain, headache.
  • Warnings: hepatic dysfunction, pancreatitis, anaphylaxis, tooth discolouration.
  • Reserve tigecycline for situations where alternative treatments are not suitable; refer to the approved prescribing information for the full list of warnings, including mortality data from clinical trials.
Composition & presentation

Product information

BrandTigradox®
GenericTigecycline
Strength50 mg per vial
Dosage formLyophilised powder for injection / infusion
PackSingle vial
Therapeutic areaAnti-infectives · critical care
Prescription statusPrescription-only medicine
ManufacturerBiogen Life Sciences, Rawalpindi
Manufacturing licence no.000911
DRAP registration no.131534
Marketed bySalventis Pharma SMC (Pvt.) Ltd., Islamabad
Resources

Prescribing information

PI
Full prescribing information — Tigradox®Provided to healthcare professionals on request by Salventis Pharma.
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For healthcare professionals. All Salventis products are prescription-only medicines, to be sold on the prescription of a registered medical practitioner. Information on this site summarises the approved prescribing information and supplied product literature; it is not a substitute for the full prescribing information, which is available on request from Salventis Pharma. To report a suspected adverse reaction, contact info@salventispharma.com.